What is the Cetrorelix acetate?

Cetrorelix acetate is White powder, while it's Molecular Formula is C70H92ClN17O14. White powder Cetrorelix Acetate is an gonadotropin-releasing hormone antagonist and is used to treat hormone-sensitive cancers of the prostate and breast.

What is the CAS number for Cetrorelix acetate?

The CAS number of Cetrorelix acetate is 120287-85-6.

What is Cetrorelix acetate (120287-85-6) used for?

Cetrorelix was launched in Germany for the treatment offemale infertility. It is a decapeptidic analog of luteinizing hormone-releasinghormone (LH-RH) bearing structural modifications in the crucial positions 1, 2, 3,6 and 10 : [Ac-D-Nal1, D-4-CI Phe-2, D-Pal3, D-Cit6, D-Alal0]-GnRH. Cetrorelixis an extremely potent and long acting gonadotrophin releasing hormone(GnRH) antagonist and thus blocks gonadotrophins and sex steroid secretionimmediately after administration. Moreover, it has a low histamine-releasingpotency. Cetrorelix will be the first LH-RH antagonist approved worldwide. Inseveral Phase III clinical trials, female patients receiving Cetrorelix had asuccessful controlled ovulation thus avoiding a premature LH-surge. Cetrorelixcould be a first-choice in-vitro fertilization (IVF) treatment without thecomplications of current controlled ovarian hyperstimulation protocols. Cetrorelixis currently under clinical investigation for the treatment of diverse sex hormonedependent disorders such as benign prostate hypertrophy, breast, ovarian orprostate cancers and diverse gynaecological disorders.InChI:InChI=1/C70H92ClN17O14/c1-39(2)31-52(61(94)82-51(15-9-28-77-69(73)74)68(101)88-30-10-16-58(88)67(100)79-40(3)59(72)92)83-60(93)50(14-8-29-78-70(75)102)81-63(96)54(34-43-20-25-49(91)26-21-43)86-66(99)57(38-89)87-65(98)56(36-45-11-7-27-76-37-45)85-64(97)55(33-42-18-23-48(71)24-19-42)84-62(95)53(80-41(4)90)35-44-17-22-46-12-5-6-13-47(46)32-44/h5-7,11-13,17-27,32,37,39-40,50-58,89,91H,8-10,14-16,28-31,33-36,38H2,1-4H3,(H2,72,92)(H,79,100)(H,80,90)(H,81,96)(H,82,94)(H,83,93)(H,84,95)(H,85,97)(H,86,99)(H,87,98)(H4,73,74,77)(H3,75,78,102)/t40-,50-,51+,52+,53-,54-,55+,56-,57-,58?/m1/s1

120287-85-6

Product NameCetrorelix acetate
Molecular FormulaC₇₀H₉₂ClN₁₇O₁₄
Molecular Weight1431.06
Purity99%
AppearanceWhite powder

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CasNo： 120287-85-6
Molecular Formula： C₇₀H₉₂ClN₁₇O₁₄
Appearance： White powder
Purity： 99%

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Molecular Formula:C70H92ClN17O14
Molecular Weight:1431.06
Appearance/Colour:White powder
Refractive Index:1.667
PKA:9.82±0.15(Predicted)
PSA：495.67000
Density:1.42 g/cm³
LogP:5.93230

Cetrorelix acetate(Cas 120287-85-6) Usage

Description	Cetrorelix Acetate, also known as SB-75 acetate, is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. It is utilized in the treatment of female infertility, particularly in controlled ovulation during in-vitro fertilization (IVF) procedures. Cetrorelix is a decapeptidic analog of luteinizing hormone-releasing hormone (LH-RH) with structural modifications at crucial positions. Notably, it bears the designation [Ac-D-Nal1, D-4-CI Phe-2, D-Pal3, D-Cit6, D-Alal0]-GnRH.
Originator	Asta Medica (Germany)
Uses	This drug acts as an extremely potent and long-acting GnRH antagonist, leading to the immediate blockade of gonadotrophins and sex steroid secretion upon administration. Additionally, it exhibits low histamine-releasing potency. Cetrorelix is distinguished as the first LH-RH antagonist approved worldwide. In Phase III clinical trials, female patients receiving Cetrorelix experienced successful controlled ovulation, preventing premature LH-surge. This positions Cetrorelix as a potential first-choice treatment for IVF, offering advantages over current controlled ovarian hyperstimulation protocols.
Brand name	Cetrotide (Serono).

InChI:InChI=1/C70H92ClN17O14/c1-39(2)31-52(61(94)82-51(15-9-28-77-69(73)74)68(101)88-30-10-16-58(88)67(100)79-40(3)59(72)92)83-60(93)50(14-8-29-78-70(75)102)81-63(96)54(34-43-20-25-49(91)26-21-43)86-66(99)57(38-89)87-65(98)56(36-45-11-7-27-76-37-45)85-64(97)55(33-42-18-23-48(71)24-19-42)84-62(95)53(80-41(4)90)35-44-17-22-46-12-5-6-13-47(46)32-44/h5-7,11-13,17-27,32,37,39-40,50-58,89,91H,8-10,14-16,28-31,33-36,38H2,1-4H3,(H2,72,92)(H,79,100)(H,80,90)(H,81,96)(H,82,94)(H,83,93)(H,84,95)(H,85,97)(H,86,99)(H,87,98)(H4,73,74,77)(H3,75,78,102)/t40-,50-,51+,52+,53-,54-,55+,56-,57-,58?/m1/s1