72957-37-0

The synthesis and reactions of a monocyclic β-lactam tripeptide, 1-[(1R)-carboxy-2-methylpropyl]- (3R -[(5S-5-amino- 5-carboxypentanamido]-(4R)-mercaptoazetidin-2-one, a putative intermediate in penicillin biosynthesis

Jack E. Baldwin ∗ a, Sir Edward P. Abraham b, Robert M. Adlington a, Michael J. Crimmin a, Leslie D. Field a, Gamini S. Jayatilake b, Robert L. White b, John J. Usher a

Tetrahedron Volume 40, Issue 10, 1984, Pages 1907-1918

The disulphide corresponding to the above thiol has been synthesised, but all attempts to reduce this substance to the thiol were unsuccessful, although an alternative procedure via a thiomercury intermediate, enabled the thiol to be generated in situ, the properties of this thiol, however, are not in accord with those previously described for a putative free intermediate in penicillin biosynthesis.

Usage of Synthetic Peptides in Cosmetics for Sensitive Skin

A Garre, J Piquero, C Trullas, G Martinez - J Cosmo Trichol, 2018

The causes of hair loss are multifactorial; therefore, there are multiple potential targets for treatment, and a combination of different active ingredients can be helpful in managing the condition. Androgenetic alopecia and telogen effluvium comprise two of the main types of hair loss, and differ in their pathophysiology. The objective of the study was to evaluate, in male and female individuals with androgenetic alopecia and telogen effluvium, the safety and efficacy of a new hair loss lotion containing a combination of cosmetic ingredients: oleanolic acid, apigenin, biotinyl tripeptide-1, 2-4diamino pyrimidine-3-oxide, adenosine, Ginkgo biloba, and biotin.