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Product Details
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Discovery |
VIP is a neuropeptide consisting of 28 aa residues, with wide distribution in the central and peripheral nervous systems. VIP has a broad spectrum of biologic actions, and acts as a neurotransmitter or neuromodulator and also as a hormone.?VIP was first discovered as a smooth muscle-relaxant vasodilator peptide in the lung; it was isolated from the porcine intestine in 1970. Its original label as a “candidate gastrointestinal hormone” was soon replaced by its new and apparently true identity as a neuropeptide with neurotransmitter and neuromodulator properties. |
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Uses |
Aviptadil induces vessel dilation, leading to increased blood flow, reduced peripheral vascular resistance, and hypotension. VIP also affects smooth muscles, exerting relaxant effects on the lower esophageal sphincter, sphincter of Oddi, anal sphincter, and bronchial smooth muscle. In the small intestine, VIP facilitates electrolyte and aqueous liquid secretion, inhibits gastric secretion in the stomach, and aids in pancreatic bicarbonate and aqueous liquid secretion. |
Volume19, Issue2February 2020 onlinelibrary.wiley
The test product of HA-MNs comprises arginine/lysine polypeptide, acetyl octapeptide-3, palmitoyl tripeptide-5, adenosine, and seaweed extracts. In the monocentric 12-week clinical trial, the HA-MNs patches were applied to the outer corner of the right and left eye and a defined area on the volar forearm on healthy subjects with aged skin.
Peptides were found in 17% of the products analyzed, namely: acetyl dipeptide-1 cetyl ester, palmitoyl tripeptide-8, acetyl tetrapeptide-15, palmitoyl tripeptide-5, acetyl hexapeptide-49, palmitoyl tetrapeptide-7 and palmitoyl oligopeptide.
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